Modelo de análise de decisão multicritério para a escolha do melhor doador de células tronco hematopoiéticas

Abstract

Allogeneic hematopoietic stem cell transplantation is used in the treatment of hematological and non-hematological diseases, transferring stem cells from a healthy donor to the patient. Donor selection is an essential strategy for the success of the transplant, requires human leukocyte antigen compatibility and considers factors such as age, sex matching, blood typing and cytomegalovirus serology. This project proposes to integrate two technology tools: REDCap (Research Electronic Data Capture) for electronic forms and DEXi for multi-criteria decision analysis. The objective was to respond to complex decision-making, choosing the best hematopoietic stem cell donor, through the analysis model of multiple qualitative parameters. Relevant criteria were selected and REDCap forms were constructed to facilitate model construction and future data collection. A DEX model based on a hierarchical decision tree was created, with values inserted by the author following pre defined decision rules and function. The analysis involved four hypothetical donors. The results highlighted donor 1 for its strong HLA, human leukocyte antigen, correspondence with the recipient, giving it greater hierarchical weight and indicating it as preferred. The DEX methodology answered the decision question with visible graphical results. The promising use of the REDCap platform and the positive evaluation of the DEXi model suggest that it is a prosperous technology in optimizing medical practice in hematopoietic stem cell transplants.