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Campo DC | Valor | Idioma |
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dc.creator | Ribeiro, Adyelle Dantas | - |
dc.creator.Lattes | http://lattes.cnpq.br/3858737000492701 | por |
dc.contributor.advisor1 | Pereira, Jozinete Vieira | - |
dc.contributor.advisor1Lattes | http://lattes.cnpq.br/8041850574045487 | por |
dc.contributor.advisor-co1 | Damasceno, Bolívar Ponciano Goulart de Lima | - |
dc.contributor.advisor-co1Lattes | http://lattes.cnpq.br/6407334157973308 | por |
dc.contributor.referee1 | Pereira, Jozinete Vieira | - |
dc.contributor.referee1Lattes | http://lattes.cnpq.br/8041850574045487 | por |
dc.contributor.referee2 | Silva, Diego Romário | - |
dc.contributor.referee2Lattes | http://lattes.cnpq.br/0522585351371155 | por |
dc.contributor.referee3 | Oliveira Filho, Abrahão Alves de | - |
dc.contributor.referee3Lattes | http://lattes.cnpq.br/7440461731944347 | por |
dc.contributor.referee4 | Damasceno, Bolívar Ponciano Goulart de Lima | - |
dc.contributor.referee4Lattes | http://lattes.cnpq.br/6407334157973308 | por |
dc.contributor.referee5 | Silva, Andrea Cristina Barbosa | - |
dc.contributor.referee5Lattes | http://lattes.cnpq.br/5097978858569561 | por |
dc.date.accessioned | 2023-08-22T11:05:11Z | - |
dc.date.available | 2999-12-31 | por |
dc.date.issued | 2023-07-31 | - |
dc.identifier.citation | RIBEIRO, Adyelle Dantas. Desenvolvimento de emulgel à base de R-(+)-limoneno para tratamento de úlceras traumáticas da cavidade oral. 2023. 111 f. Tese (Programa de Pós-Graduação em Odontologia - PPGO) - Universidade Estadual da Paraíba, Campina Grande, 2023. | por |
dc.identifier.uri | http://tede.bc.uepb.edu.br/jspui/handle/tede/4722 | - |
dc.description.resumo | As úlceras traumáticas (UTs) da mucosa oral consistem em um grupo de alterações comuns na cavidade oral que provocam sintomatologia dolorosa e afetam o bem-estar do paciente acometido. As terapias disponíveis para o tratamento dessas lesões possuem limitações em relação a aplicação e ocorrência de efeitos adversos. Nesse contexto, destaca-se a busca de novas alternativas terapêuticas, provenientes de plantas medicinais, como o limoneno, um terpeno que apresenta propriedades de interesse farmacológico. Esse estudo avaliou in silico e in vitro, a atividade antifúngica do R-(+)-limoneno isolado sobre Candida spp, e incorporado a um emulgel suas propriedades físico-químicas, ação antifúngica, toxicológica, anti-inflamatória e cicatrizante deste emulgel. Por meio do ensaio in silico, foi avaliada a probabilidade do potencial biológico do monoterpeno, sua biodisponibilidade oral teórica e toxicidade oral aguda. Foram utilizadas as cepas: C. albicans ATCC 10231, C. glabrata ATCC 90031, C. krusei ATCC 6258, C. tropicalis ATCC 750, C. parapsilosis (ATCC 22019) e isolados clínicos de C. albicans A1, e C.albicans A2. Determinou-se a Concentração Inibitória Mínima (CIM), Concentração Fungicida Mínima (CFM) por microdiluição, seu efeito sobre a cinética de crescimento de C. albicans e o potencial antifúngico por redução logarítmica. As propriedades físico-químicas do emulgel à base de R-(+)-limoneno (ELI) foram determinadas por meio do pH, da resistência à centrifugação, viscosidade e espalhabilidade. A toxicidade oral aguda e o potencial clastogênico e aneugênico foram avaliados em camudongos Mus musculus (2000mg/kg). Ratos Wistar foram submetidos a aplicação de ácido acético a 5% em mucosa jugal para avaliar o potencial anti-inflamatório e cicatrizante da formulação, por meio de análise clínica e histopatólogica. Os dados foram analisados por estatística descritiva e inferencial, analisados através do software GraphPad Prism 5.0®, San Diego, CA, EUA. Os ensaios in silico estimaram que o R-(+)-limoneno apresenta um amplo espectro de ação sobre microrganismos de grande importância clínica. A CIM do R-(+)-limoneno variou na faixa de 656,25 µg/mL a 2625 µg/mL e se classificou como fungistático sobre a cepa de C. albicans (ATCC 10231), enquanto para as demais espécies sua ação foi fungicida. O R-(+)-limoneno apresentou potencial efeito significativo sobre a cinética de crescimento de C.albicans (p<0,05). O ELI apresentou pH de caráter ácido, de 5,71 ± 0,11; 5,71 ± 0,09 e 5,97 ± 0,05 para formulação do emulgel com R-(+)-limoneno (ELI) a 1,2%, 2,4% e 5%, respectivamente, e 5,74 ± 0,21 para a formulação controle, boa estabilidade e espalhabilidade, assim como boa viscosidade. Por meio das análises da cinética de crescimento e da redução logarítimica, pode-se constatar que o produto inibiu significativemente o crescimento de C.albicans em todas as diferentes concentrações testadas quando comparado ao controle de crescimento. O ELI não induziu sinais de toxicidade aguda nos camudongos submetidos ao tratamento por gavagem na dose única de 2000 mg/kg e produziu um menor número de micronúcleos estatisticamente significativo comparado ao controle positivo (ciclofosfomida a 50 mg/kg) em eritrócitos de camudongos. O R-(+)-limoneno demonstrou ser um potencial agente antifúngico contra espécies de Candida, tanto como composto isolado como incorporado ao emulgel. O ELI apresentou baixa toxicidade e mutagenicidade, além de uma boa ação anti-inflamatória e cicatrizante no tratamento de UTs na cavidade oral de ratos Wistar. Portanto, a formulação desenvolvida foi considerada promissora para o tratamento de UTs na cavidade oral. | por |
dc.description.abstract | Traumatic ulcers (UTs) of the oral mucosa consist of a group of common changes in the oral cavity that cause painful symptoms and affect the well-being of the patient. The therapies available for the treatment of these injuries are isolated in terms of application and the occurrence of adverse effects. In this context, the search for new therapeutic alternatives from medicinal plants, such as limonene, a terpene with properties of pharmacological interest, stands out. This study evaluated in silico and in vitro, the antifungal activity of R-(+)-limonene isolated on Candida spp, and incorporated into an emulgel its physicochemical properties, antifungal, toxicological, anti-inflammatory and healing action of this emulgel. Through the in silico assay, the probability of the biological potential of the monoterpene, its theoretical oral bioavailability and acute oral toxicity were evaluated. The following strains were used: C. albicans ATCC 10231, C. glabrata ATCC 90031, C. krusei ATCC 6258, C. tropicalis ATCC 750, C. parapsilosis (ATCC 22019) and clinical isolates of C. albicans A1, and C. albicans A2. The Minimum Inhibitory Concentration (MIC), Minimum Fungicide Concentration (MFC) was determined by microdilution, its effect on the growth kinetics of C. albicans and its antifungal potential by logarithmic reduction. The physical-chemical properties of the emulgel based on R-(+)-limonene (ELI) were determined by means of pH, resistance to centrifugation, accelerated centrifugation and spreadability. Acute oral toxicity and clastogenic and aneugenic potential were evaluated in Mus musculus mice (2000mg/kg). Wistar rats were submitted to the application of 5% acetic acid in the buccal mucosa to evaluate the anti-inflammatory and healing potential of the formulation, through clinical and histopathological analysis. Data were analyzed using descriptive and inferential statistics, analyzed using GraphPad Prism 5.0® software, San Diego, CA, USA. The in silico assays estimated that R-(+)-limonene has a broad spectrum of action on microorganisms of great clinical importance. The MIC of R-(+)-limonene ranged from 656.25 µg/mL to 2625 µg/mL and was classified as fungistatic on the C. albicans strain (ATCC 10231), while for the other species its action was fungicide. R-(+)-limonene had a potentially significant effect on the growth kinetics of C. albicans (p<0.05). The ELI showed an acidic pH of 5.71 ± 0.11; 5.71 ± 0.09 and 5.97 ± 0.05 for formulation of the emulgel with R-(+)-limonene (ELI) at 1.2%, 2.4% and 5%, respectively, and 5.74 ± 0.21 for the control formulation, good stability and spreadability, as well as good viscosity. Through analysis of growth kinetics and logarithmic reduction, it can be seen that the product significantly inhibited the growth of C. albicans in all the different concentrations tested when compared to the growth control. ELI did not induce signs of acute toxicity in mice submitted to gavage treatment at a single dose of 2000 mg/kg and produced a statistically significant lower number of micronuclei compared to the positive control (cyclophosphamide 50 mg/kg) in mouse erythrocytes. R-(+)-limonene has been shown to be a potential antifungal agent against Candida species, both as an isolated compound and incorporated into the emulgel. The ELI showed low toxicity and mutagenicity, in addition to good anti-inflammatory and healing action in the treatment of UTs in the oral cavity of Wistar rats. Therefore, the developed formulation was considered promising for the treatment of UTs in the oral cavity. | eng |
dc.description.provenance | Submitted by Adyelle Ribeiro (adyelle.ribeiro@aluno.uepb.edu.br) on 2023-08-20T18:57:32Z No. of bitstreams: 2 TESE.pdf: 2804948 bytes, checksum: 1e5fce1976e9cb93fc59be3fbc25b169 (MD5) Termo de Depósito BDTD.pdf: 161528 bytes, checksum: fab0625b459776ae5c6d20d11d0915ac (MD5) | eng |
dc.description.provenance | Approved for entry into archive by Rosalvo Andrade (rosalvo_andrade@servidor.uepb.edu.br) on 2023-08-21T23:16:29Z (GMT) No. of bitstreams: 2 TESE.pdf: 2804948 bytes, checksum: 1e5fce1976e9cb93fc59be3fbc25b169 (MD5) Termo de Depósito BDTD.pdf: 161528 bytes, checksum: fab0625b459776ae5c6d20d11d0915ac (MD5) | eng |
dc.description.provenance | Made available in DSpace on 2023-08-22T11:05:11Z (GMT). No. of bitstreams: 2 TESE.pdf: 2804948 bytes, checksum: 1e5fce1976e9cb93fc59be3fbc25b169 (MD5) Termo de Depósito BDTD.pdf: 161528 bytes, checksum: fab0625b459776ae5c6d20d11d0915ac (MD5) Previous issue date: 2023-07-31 | eng |
dc.format | application/pdf | * |
dc.language | por | por |
dc.publisher | Universidade Estadual da Paraíba | por |
dc.publisher.department | Pró-Reitoria de Pós-Graduação e Pesquisa - PRPGP | por |
dc.publisher.country | Brasil | por |
dc.publisher.initials | UEPB | por |
dc.publisher.program | Programa de Pós-Graduação em Odontologia - PPGO | por |
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dc.rights | Acesso Embargado | por |
dc.subject | Fitoterapia | por |
dc.subject | Úlceras traumáticas | por |
dc.subject | Mucosa oral | por |
dc.subject.cnpq | CIENCIAS DA SAUDE::ODONTOLOGIA | por |
dc.title | Desenvolvimento de emulgel à base de R-(+)-limoneno para tratamento de úlceras traumáticas da cavidade oral | por |
dc.title.alternative | Development of emulgel based on R-(+)-limonene for the treatment of traumatic oral cavity ulcers | eng |
dc.type | Tese | por |
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