Efeito da composição do infiltrante resinoso no volume ocluído por resina na lesão cariosa natural de esmalte

Abstract

Introduction: Dental caries is one of the most prevalent chronic diseases in the world and caries infiltration is a promising therapeutic method for its approach between preventive and restorative actions in the treatment of early carious lesions. Objective: To evaluate whether resin composition affects the volume of pores occluded by infiltrant in natural enamel carious lesions. Methodology: 51 natural proximal enamel carious lesions, being inactive white spot lesions without cavitation were selected by a calibrated examiner for sample preparation by wear cutting. 1 histological point in the surface layer and 4 in the central region of the lesion body were selected to quantify mineral volumes (V1) through gray levels obtained from MicroCT imaging, organic (β), total water (α) and infiltrating resin infiltrated volume (α2) and main endpoint from phase delays in Image J. The endpoint was the infiltrating resin infiltrated volume (αinfilt) divided by the percentage of total water that was removed by dehydration (α2/α). The samples were separated into three groups: Icon Group: 17 samples infiltrated with Icon®; TB Group: 17 samples infiltrated with experimental infiltrating resin with TEGDMA 75% + BisEMA 25%; TH Group: 17 samples infiltrated with experimental infiltrating resin with TEGDMA 80% + HEMA 20%. Results: Icon Group: 74 points; TB Group: 74 points; TH Group: 71 points, totaling 219 histological points. The volume occluded by infiltrating resin in the Icon® group varied by approximately 1 and 17%, in the TB group by 0 to 15%, and in the TH group by 0 to 16%. The total water volume data were strongly associated with the a2inf/a2 ratio (n of 219, r coefficient of 0.52, 95% CI of 0.42 to 0.61, p value < 0.0001, and power greater than 99.9). The Kruskal-Wallis test showed there was an effect on the outcome (p-value = 5.445e-08; eta squared effect size of 0.146 [95% CI = 0.08;0.124]). Values obtained for median and 75% interquartile difference (DIQx0.75): ICON (n=74; median=0.048999; DIQx0.75=0.009306); TB (n=74; median=0.051085; DIQx0.75=0.007456); TH (n=71; median=0.056805; DIQx0.75=0.0092380). Unpaired pairsof- groups Mann Whitney tests were performed between TH X TB (Cohen d: 0.69; 95% CI: 0.36;1.03; p value: 1.121e-07); TH X ICON (Cohen d: 0.84; 95% CI: 0.50;1.18; p value: 2.445e-06) and TB X ICON (Cohen d:0.24; 95% CI: -0.56;0. 09; p value: 0.8225) and it was observed that there is a treatment effect, with the TH group having greater infiltration than the TB (mean effect size of 0.69) and Icon (large effect size of 0.84) groups, with very low p values and 95% CI not including the null hypothesis. Conclusion: Within the limitations of this study, it was concluded that the composition of the infiltrant alters the volume occluded by infiltrating resin and that the group with hydrophilic characteristics (TH) resulted in a greater potential for penetration when compared to the Icon® group and the group with hydrophobic characteristics (TB).