Desenvolvimento e caracterização de filmes de xilana e gelatina para obtenção de formulações farmacêuticas transdérmicas

Abstract

Biodegradable films prepared from biopolymers such as polysaccharides, proteins, lipids or combinations of those components have received great interest in recent years. Xylan is the major hemicellulose in the plant kingdom and it accounts for onethird

of renewable biomass available on earth. The aim of this work was to develop and characterize biodegradable films of xylan from corn cobs with potential use as transdermal formulations. Films were produced by casting the film-forming dispersions with different concentrations of xylan and glycerol. In addition, the gelatin was incorporated to xylan films. According to macroscopic characterization, three films were selected to evaluate the thickness, solubility, biodegradability, opacity, water content and microscopic morphology of the films. The best formulation was selected to study the incorporation of the drug (drug content and release profile). The results show that the macroscopic aspect of xylan/gelatin films was better than films containing only xylan, probably due the high solubility of the gelatin in the films. The increase in the polysaccharide concentration affected the films solubility, opacity, water content and thickness of films. The drug content was 87.88% and the drug release occurred mainly in the first 4h, followed by a slow release until the end of the study.