Filmes poliméricos de acetato de celulose contendo o derivado espiro-acridínico AMTAC 06

Abstract

Polymeric films are drug delivery systems used on the skin in which the drug is solubilized in the film-forming agent and released gradually. The objective of this work is to develop a polymeric film based on cellulose acetate containing a spiro-acridinic derivative AMTAC 06, which has promising leishmanicidal activities, aiming at the auxiliary treatment of cutaneous leishmaniasis. The production of the films with and without the incorporation of AMTAC 06 was carried out by the casting technique, which consists of the evaporation of the solvent and subsequent characterization using the techniques of Bending Strength, Degree of swelling, wettability by contact angle, optical microscopy (OM) , scanning electron microscopy (SEM); spectroscopy in the infrared region with Fourier transform (FITR); X-ray diffraction (XRD); thermogravimetric analysis (TG) and differential thermal analysis (DTA). The results obtained show that the films formed with AMTAC 06 are resistant and have swelling power and hydrophilic behavior, important characteristics for a dressing to absorb fluids from injuries, accelerating the healing process. The MO and SEM analyzes showed the appearance of accentuated roughness, when compared to the films without the incorporation of AMTAC 06, which may be indicative of crystals dispersed throughout the surface of the film, thus evidencing its presence in the film. The FTIR expressed the main functional groups of the evaluated samples, indicating that there was the incorporation of AMTAC 06. The XRD indicated a decrease in the intensity of the crystalline reflection peaks, with an increase in the halo formed, thus showing the amorphization process with the incorporation of the AMTAC 06 in the movie. TG/DTG and DTA allowed an analysis of the formulation components isolated and incorporated in the films, indicating that there were no interactions. In this way, the results obtained from the techniques used for the characterization of the films, are promising for the development of these dressings as a proposal for a complementary topical treatment related to the skin lesions presented in TL.