Análise da sequência e cronologia de erupção da dentição decídua de crianças com microcefalia associada ao ZIKV: uma coorte dinâmica

Abstract

Objective: To describe the timing and sequence of primary teeth eruption of children with Zika Virus-associated microcephaly (ZIKV). Method: Longitudinal study (27 months) conducted in the city of Campina Grande (PB) - Brazil, with 74 children of both sexes with congenital ZIKV syndrome who had microcephaly. The tooth was considered erupted when the crown crossed the gum and became part of the oral environment. Descriptive statistics were used, in addition to Fisher's Exact and Student's t tests for independent samples. Data were analyzed in the Statistical Package for Social Sciences (SPSS version 20.0). Results: Most children were female (54.1%) and 14.9% were born premature. The mean gestational age was 38.2 (± 1.9) weeks, while length, weight and head circumference at birth were 45.6 (± 3.1) cm, 2750 (± 526.6) and 30 (± 2,3) cm, respectively. First tooth eruption occurred on average at 12.3 (± 3.0) months of age. The first erupted teeth were the lower central incisors (82.4%). The mean age for tooth eruption in males was 12.5 months (± 3.0) and in females, 12.0 months (± 3.1). For children who were followed until the eruption of 20 teeth (n = 25), a sequence of atypical eruption was observed. 76.0% of cases (n = 19). Regarding eruption chronology, for the upper teeth no statistically significant differences were identified in the mean eruption age (p-values> 0.05). In contrast, for the lower teeth, it was found that the mean age of tooth eruption 72 and 74 was significantly lower for males compared to females (p <0.05). Conclusion: In this population of children with microcephaly affected by congenital Zika virus syndrome, the first tooth to erupt was the lower central incisor around the first year of life. The children presented delayed tooth eruption and sequence of atypical eruption