Lipoproteína (a) e fatores de risco cardiovascular em crianças e adolescentes

Abstract

Objective: Investigate the relation between serum levels of lipoprotein (a) [Lp (a)] with cardiovascular risk factors in overweight or obese children and adolescents. Material and Methods: Article 1 - A systematic review was performed, researching studies from 2001 to 2011 in the databases Science Direct, PubMed / Medline, LILACS and Cochrane Library. Article 2 - Was directed a cross-sectional study from July 2011 to May 2012, with 165 overweight or obese children and adolescents, attended at the Childhood Obesity Center in Campina Grande-PB. The association and comparison between Lp (a) and the study variables was performed using the chi-square test and analysis of variance. Statistical analysis was performed with SPSS version 17.0, considering a confidence interval of 95%. Results: In the review was observed a positive correlation between: Lp (a) and LDL cholesterol, total cholesterol and apolipoprotein B. In the second article, Lp (a) was altered in 40.0% of patients and its mean in the sample was 29.7 (± 28.1) mg / dL, and being associated with insulin (p = 0.026) and low HDL cholesterol (p = 0.049). The Lp (a) mean in relation to the risk factors analyzed was higher in children. Conclusion: The Lp (a) was associated with some cardiovascular risk factors, emphasizing the importance of analyze this serum levels in this population in order to contribute to the prevention of cardiovascular disease, as well as public health by reducing unnecessary government spending in this segment.